今天有朋友问，氢气对颈动脉斑块是否有作用？印象中没有这方面的临床试验，但毕竟文献越来越多，怕记不住，就pub了下，寻找到37篇和血管健康相关的文献。总体上来说，从2008年太田课题组研究氢水对动脉硬化动物模型效应研究后，中国学者进行了各方面的血管健康相关研究，其中包括血脂紊乱相关的临床试验，但确实没有对人类动脉斑块的临床研究。研究比较集中的团队是山东第一医科大学秦树存宋国华教授小组。该团队也进行了人体血脂紊乱和心绞痛等临床试验。
     动脉斑块是比较客观的动脉硬化影像学证据，具有重要临床价值。氢气和氢水如果对动脉硬化真正具有作用，确实应该从这个指标上进行研究。我记得多年前有临床医生认为，进行这个研究条件比较好，因为临床上有许多患者进行颈内动脉斑块的检测。只是担心氢气是否能产生这么大的作用。我认为可以结合临床上使用的他汀类药物，某些患者不愿意服用他汀的，可作为比较重要的单独用氢的一组。不过动脉硬化的产生需要很长时间，有效的逆转和干预手段也需要足够长时间。这可能给临床试验带来额外的困难。

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